The sovereignty of God is the most encouraging and comforting doctrine in all of Scripture. An understanding of it removes the anxiety from life. It also gives the man of God courage in spiritual duty and willingness to face any danger. God is never surprised, nor is His will ever frustrated. He says in Isaiah 46:11, “Truly I have spoken, truly I will bring it to pass. I have planned it, surely I will do it.” Because He is in total control, there is no need to worry, to compromise, to equivocate, or to manipulate to achieve a goal.
The man of God knows that the success of his ministry does not depend on his ingenuity, wisdom, or talent. He is relieved of the intolerable burden of imagining that people’s eternal destiny rests on the persuasiveness of his preaching or the cleverness of his invitation. He understands that no one comes to faith in Christ apart from God’s gracious, sovereign choice. And he, too, is operating under the constant surveillance of and within the plan of the God who is in perfect control of everything. That frees him to focus on faithfully expounding the Word and fulfilling his calling with contentment.
– John MacArthur, The MacArthur New Testament Commentary: 1 Timothy, (Moody Publishers: 1995), 276.